The 2021 Monaco Grand held on 23 May 2021 at the Circuit de Monaco,  was the fifth round of the 2021 Formula One World Championship, the 78th time that the Monaco Grand Prix was held, and the first time it had been held since 2019 after the 2020 round was cancelled due to the COVID-19 pandemic. Carlos Sainz with this Ferrari SF-21 ended 3rd.

Ferrari inspected Charles Leclerc's car overnight after his crash in qualifying. The primary concern was Leclerc's gearbox, but it was cleared, and it was expected that Leclerc would start on pole. On race day, Leclerc brought the car out from the pits on the reconnaissance lap out to the grid, and a failure in the left driveshaft was detected. There was not enough time to repair the problem before the race, and thus Leclerc did not start in the race.[

Due to Leclerc's failure to start the race, pole position on the grid was left empty, leaving Max Verstappen as the de facto polesitter, though he lined up in the second grid position. At the start of the race Valtteri Bottas got away slightly better than Verstappen, but the latter was able to cover off the former to take the lead into the first corner. Bottas later retired at his scheduled pitstop on lap 30, when his team was unable to remove his right front wheel due to a stripped wheel nut, promoting Carlos Sainz to second place and Lando Norris to third. Verstappen pitted for fresh tyres on lap 34. Sergio Pérez led most of lap 35 before being called into the pits at the end of the same lap, and this meant that Verstappen officially led all laps through the pit stops. Pérez used pit strategy to improve to fourth, which is where he finished the race. The podium was formed by the same drivers in those positions at the halfway point of the race: Verstappen in the lead, Sainz in second, and Norris in third. Pérez, in fourth, closed in on Norris but was unable to pass him before the race ended. Sebastian Vettel and Antonio Giovinazzi scored their first points of the season, finishing fifth for Aston Martin and 10th for Alfa Romeo, respectively. This was also Alfa Romeo's first point of the season

Three former Monaco Grand Prix winners, Kimi Räikkönen, Daniel Ricciardo, and Fernando Alonso, all finished one lap down on race winner Verstappen and out of the points in 11th, 12th and 13th places respectively.[  Verstappen's and Pérez's high points haul, along with Bottas' retirement and Hamilton's seventh-place finish, was sufficient to propel Red Bull into the lead in the Constructors' Championship, and Verstappen into the lead in the Drivers' Championship. This was the first time since the 2018 British Grand Prix that Mercedes had not led either championship. It was also the first time Verstappen was the points leader in his Formula One career.[20] The FIA said it was open to suggesting layout changes for the future to the improve the on track excitement at the venue, after the race provided just one on-track overtake.

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